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In one study, curcumin inhibited the secretion of matrix metalloproteins (MMPs) responsible for the degradation of the synovial joints in human fibroblast-like synoviocytes and in human articular chondrocytes.Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival.Nutritionists, functional medicine GPs and physiotherapists commonly use curcumin for its anti-inflammatory qualities.And its no wonder considering six major scientific trials all found curcumin to possess a potent anti-inflammatory action, which is completely non-toxic in nature.But now in our modern world, the environment and exposure to pathogens has changed, and the genetic variants that were originally meant to protect us, now make an autoimmune reaction more likely.These results are consistent with the hygiene hypothesis in which our cleaner environment is thought to contribute to the increasing prevalence of inflammatory diseases.Curcumin also helps the endothelium (the lining of blood vessels) to function at its optimum level, similar to the effect found during intense exercise.
Whether we are healing from an injury or an autoimmune disease, inflammation is a common health challenge.
Therefore, by improving endothelial function, curcumin lowers your risk of heart disease.
In addition to helping out the endothelium, curcumin also reduces inflammation and oxidative damage, two factors that are also common contributors to heart disease.
At the end of the six days, those taking the Curcumin and the NSAID enjoyed a significantly better anti-inflammatory response than placebo. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
The spice worked as well as the drug, but without the negative side effects. Curcumin has also been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (i NOS).